Some might argue that early U.S. intervention would have at least empowered "our guys" at the expense of Assad and may have headed off al-Qaeda. The second claim seems completely false -- if rebel groups were able to depose Assad, al-Qaeda would almost certainly have slipped into the country in the resultant chaos (unless you make the over-confident assumption that U.S.-backed rebels would have quickly locked down the entire country). As for deposing Assad, it's probably true that U.S. support early on could have tipped the balance -- but again, it would have tipped the balance toward just as much chaos. Only in that instance, the U.S. would bear a much greater responsibility for the destruction and would be under even more pressure to step up its involvement to clean up the resulting mess.