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The Libyan rebellion's successful ouster of a 42-year dictatorial elite is but one example of successful regime change. Another is the ongoing attempt by Syrians to end a nearly half-century dictatorship. A few months ago, few would have believed those revolutions would occur. Moreover, an Iranian uprising will be directed against Islamists, not by them. Were Iran's theocrats gravely weakened or swept away, Iran's sponsorship of terrorists and dictatorships would come to a halt-making groups like Hamas and Hezbollah, and leaders like Bashar al-Assad, Kim Jong Il and Hugo Chávez more vulnerable.

A new Iranian nation would require economic aid and political guidance-from the U.S. and Europe-to develop representational governance. That would be a worthwhile investment. Crucially, even if a post-theocratic Iranian state gradually rebuilds its military and resumes its nuclear program, the weapons would not be in the hands of a regime so hostile to much of the world.

Regime change remains the best option for defusing the ayatollahs' nuclear threat, and it can best be achieved by the Iranian people themselves. Disabling the theocracy's machinery of repression would leave it vulnerable to popular revolt. Through such decisive actions, the U.S. and its allies could help Iranians bring the populist uprising of 2009 to a fitting culmination.