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These cash-happy Islamists have been the main targets of the U.S.-led sanctions. Contrary to claims of anti-sanction activists in the West, the Guard's vast economic concerns have been badly bruised by the oil and banking sanctions implemented by Western nations.

To keep the nuclear program afloat and maintain their many business interests, the Revolutionary Guard's money men are forced to sell oil below international rates. Khamenei's adamant refusal to reach a compromise over the nuclear program has boxed Iran into a corner and cost them billions of dollars.

In Tehran's political circles, knowledgeable people are divided as to whether the nuclear crisis will lead to war or find a peaceful resolution. But the latter is only possible if the Revolutionary Guard sidelines Khamenei and forces a compromise. So far, Khamenei has retained the upper hand.

In addition to stymieing the Revolutionary Guard, Khamenei will sabotage any effort by other factions of the Islamic Republic to engage diplomatically with the West. The clerical establishment, which is deeply disaffected from Khamenei, is so economically dependent on the government that it cannot affect Iranian politics in a meaningful way. The old merchant class, equally disaffected, no longer plays a significant economic or political role.

Reformists like onetime president Akbar Hashemi Rafsanjani are gradually being pushed out of the political arena. In March, Mr. Rafsanjani may lose his only remaining position of influence-as head of the regime's Expediency Council, which advises the supreme leader.

In this environment, any further effort to engage Khamenei would be futile. A wiser course would be to prepare now to open channels of communication with Revolutionary Guard leaders, who are surely busy planning ways to address the mounting pressure of international sanctions. These are the people who will determine Khamenei's successor and whose anger may even lead them to take the reins of the country before he dies. While they are not closet liberals ready for a Tehran Spring, in the aftermath of Khamenei's regime they will have their own legitimacy crisis that may compel them to open up abroad in order to consolidate power, popularity and credibility at home.

The Revolutionary Guard, guilty of acts of terror at home and abroad, is by no means a natural partner for the West. But its leaders, with their myriad economic interests and sensitivity to sanctions, are far more inclined than Khamenei to strike a deal on Iran's nuclear program. Considering the alternatives, it's an opportunity worth pursuing.